(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - Names and Identifiers

Name	(3-chloro-2-hydroxypropyl)trimethyl-ammonium chloride S.
Synonyms	nt21 AURORA KA-6872 CHLOROHYDROXY PROPYLTRIMETHYL AMMONIUMCHLORIDE 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride (3-chloro-2-hydroxypropyl)trimethyl-ammoniuchloride (3-Chloro-2-hydroxypropyl)trimethylammonium chloride (3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE (3-chloro-2-hydroxypropyl)trimethyl-ammoniumchlorides. (3-CHLORO-2-HYDROXY-N-PROPYL)TRIMETHYLAMMONIUM CHLORIDE (3-chloro-2-hydroxypropyl)trimethyl-ammonium chloride S. 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride 1-Propanaminium,3-chloro-2-hydroxy-N,N,N-trimethyl-,chloride
CAS	3327-22-8
EINECS	222-048-3
InChI	InChI=1/C3H8ClNO.ClH/c4-1-3(6)2-5;/h3,6H,1-2,5H2;1H

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - Physico-chemical Properties

Molecular Formula	C6H15Cl2NO
Molar Mass	188.1
Density	1.154g/mLat 25°C
Melting Point	191-193°C
Boling Point	240.2°C at 760 mmHg
Flash Point	>230°F
Water Solubility	835.2g/L at 20℃
Vapor Presure	0.001Pa at 20℃
Appearance	clear liquid
Color	Colorless to Light yellow
BRN	6576172
PH	4.8 to 6.4(50g/L, 25℃)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	n20/D 1.4541
Physical and Chemical Properties	Colorless transparent liquid, easily soluble in water and 2-propanol. The pure product is a white crystal with a melting point of 191~193 ℃ and a flash point of 113 ℃.
Use	This product is a reactive cationic reagent that can be used to prepare cationic cellulose, printing and dyeing fixing agents, anti-static agents, etc.

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R40 - Limited evidence of a carcinogenic effect
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	2811
WGK Germany	2
RTECS	BP5275400
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LDLo subcutaneous in mouse: 500mg/kg

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - Preparation method

Open Data Verified Data

After adding a certain amount of concentrated hydrochloric acid to the reaction kettle, stir and add a trimethylamine aqueous solution. Control the reaction temperature to not exceed 30 ℃. After the reaction is completed, use trimethylamine to adjust the pH value of the solution to 7.5-8. The reaction formula is as follows: (CH:) N+HCl → → (CH:) N · HC Add the generated trimethylamine hydrochloride and water to the reaction pot, stir and heat to 40 ℃, add epichlorohydrin dropwise, control the temperature to 40-45 ℃, add it, and continue the insulation reaction for 2.5 hours. After the reaction is completed, concentrate, reflux with ethanol to dissolve, cool, crystallize, and centrifuge dry to obtain the finished product.

Last Update：2024-01-02 23:10:35

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - safety

Open Data Verified Data

This product has a slight irritating effect on the eyes, skin, and respiratory tract. It should be sealed and stored in a dry and cool place.

Last Update：2023-10-25 10:13:05

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE - Reference Information

LogP	-1.5 at 25℃
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Use	The product can be chlorinated (γ-trimethylammonium-β-hydroxybutyric acid) after cyanidation and hydrolysis. This is a drug used to treat digestive organ dysfunction, also known as vitamin BT. Used for the preparation of cationic starch, cationic polyacrylamide, electroplating additives, textile printing and dyeing auxiliaries, antistatic agents and papermaking auxiliaries, etc. AT-10 liquid cationic etherifying agent as a cationic auxiliaries can be widely used in the following fields:(1) The paper industry is mainly used as a liquid cationic etherifying agent, which is widely used in the modification of cellulose, cellulose derivatives and starch; it reacts with starch to obtain cationic starch, it can be used as an internal sizing adhesive for paper, paper reinforcing agent, filler and auxiliary agent for fine fiber retention. (2) The AT-10 liquid cationic etherifying agent in the textile industry reacts with cotton fibers to improve the adhesion of dyes; it reacts with starch to obtain cationic starch, which can be used as a warp sizing agent. (3) The suspended solids in the water treatment industry are negatively charged, and the cationic polymer formed by the reaction with AT-10 liquid cationic etherifying agent is widely used as a flocculant for water purification. (4) Cationic guar gum generated by the reaction of daily chemical industry and AT-10 liquid cationic etherifying agent are all important daily chemicals.
production method	add trimethylamine hydrochloride and water to the reaction pot, stir and heat to 40 ℃, add epichlorohydrin dropwise, control the temperature to 40-45 ℃, finish the addition, continue the heat preservation reaction for 2.5h, concentrate to dry, add ethanol reflux to dissolve, cool and crystallize, centrifuge and dry, N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride was obtained.
category	toxic substances
toxicity classification	poisoning
acute toxicity	subcutaneous-mouse LDL0: 500 mg/kg
flammability hazard characteristics	flammability; fire field decomposition of toxic chloride, nitrogen oxide gas
storage and transportation characteristics	warehouse low temperature, ventilation, drying
fire extinguishing agent	water, carbon dioxide, dry powder, sand

Last Update：2024-04-09 19:05:09

(3-CHLORO-2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE

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